Publications
Subramania S, Gagne LM, Campagne S, Fort V, O'Sullivan J, Mocaer K, Feldmuller M, Masson JY, Allain FHT, Hussein SM, Huot MESAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing. Nucleic Acids Res, 47 (8), p. 4181-4197, 2019, ISSN: 0305-1048.
Kim KH, Kim YH, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Yoo JA, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SM, Doh KO, Hui CC, Sung HK. Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. Cell Res, 27 (11), p. 1309-1326, 2017, ISSN: 1001-0602.
Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH. Irx3 is required for postnatal maturation of the mouse ventricular conduction system. Sci Rep, 6, p. 19197, 2016, ISSN: 2045-2322.
Tonge PD, Corso AJ, Monetti C, Hussein SM, Puri MC, Michael IP, Li M, Lee DS, Mar JC, Cloonan N, Wood DL, Gauthier ME, Korn O, Clancy JL, Preiss T, Grimmond SM, Shin JY, Seo JS, Wells CA, Rogers IM, Nagy A. Corrigendum: Divergent reprogramming routes lead to alternative stem-cell states. Nature, 523 (7562), p. 626, 2015, ISSN: 0028-0836.
Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A. Corrigendum: Genome-wide characterization of the routes to pluripotency. Nature, 523 (7562), p. 626, 2015, ISSN: 0028-0836.
Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SM, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJ, Wollscheid B, Nagy A, Zandstra PWCD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun, 6, p. 7329, 2015, ISSN: 2041-1723.
Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Le Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A. Genome-wide characterization of the routes to pluripotency. Nature, 516 (7530), p. 198-206, 2014, ISSN: 0028-0836.
Tonge PD, Corso AJ, Monetti C, Hussein SM, Puri MC, Michael IP, Li M, Lee DS, Mar JC, Cloonan N, Wood DL, Gauthier ME, Korn O, Clancy JL, Preiss T, Grimmond SM, Shin JY, Seo JS, Wells CA, Rogers IM, Nagy A. Divergent reprogramming routes lead to alternative stem-cell states. Nature, 516 (7530), p. 192-7, 2014, ISSN: 0028-0836.
Benevento M, Tonge PD, Puri MC, Hussein SM, Cloonan N, Wood DL, Grimmond SM, Nagy A, Munoz J, Heck AJ. Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks. Nat Commun, 5, p. 5613, 2014, ISSN: 2041-1723.
Clancy JL, Patel HR, Hussein SM, Tonge PD, Cloonan N, Corso AJ, Li M, Lee DS, Shin JY, Wong JJ, Bailey CG, Benevento M, Munoz J, Chuah A, Wood D, Rasko JE, Heck AJ, Grimmond SM, Rogers IM, Seo JS, Wells CA, Puri MC, Nagy A, Preiss T. Small RNA changes en route to distinct cellular states of induced pluripotency. Nat Commun, 5, p. 5522, 2014, ISSN: 2041-1723.
Lee DS, Shin JY, Tonge PD, Puri MC, Lee S, Park H, Lee WC, Hussein SM, Bleazard T, Yun JY, Kim J, Li M, Cloonan N, Wood D, Clancy JL, Mosbergen R, Yi JH, Yang KS, Kim H, Rhee H, Wells CA, Preiss T, Grimmond SM, Rogers IM, Nagy A, Seo JS. An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator. Nat Commun, 5, p. 5619, 2014, ISSN: 2041-1723.
Michael IP, Westenskow PD, Hacibekiroglu S, Greenwald AC, Ballios BG, Kurihara T, Li Z, Warren CM, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein SM, Sung HK, Iruela-Arispe ML, Rini JM, van der Kooy D, Friedlander M, Nagy A. Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med, 6 (5), p. 604-23, 2014, ISSN: 1757-4676.
Laurila K, Autio R, Kong L, Narva E, Hussein S, Otonkoski T, Lahesmaa R, Lahdesmaki H. Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells. BioData Min, 7 (1), p. 32, 2014.
Hussein SM, Elbaz J, Nagy AA. Genome damage in induced pluripotent stem cells: assessing the mechanisms and their consequences. Bioessays, 35 (3), p. 152-62, 2013, ISSN: 0265-9247.
Carlsson E, Krohn K, Ovaska K, Lindberg P, Hayry V, Maliniemi P, Lintulahti A, Korja M, Kivisaari R, Hussein S, Sarna S, Niiranen K, Hautaniemi S, Haapasalo H, Ranki A. Neuron navigator 3 alterations in nervous system tumors associate with tumor malignancy grade and prognosis. Genes Chromosomes Cancer, 52 (2), p. 191-201, 2013, ISSN: 1045-2257.
Hussein SM, Nagy AA. Progress made in the reprogramming field: new factors, new strategies and a new outlook. Curr Opin Genet Dev, 22 (5), p. 435-43, 2012, ISSN: 0959-437X.
Ji J, Ng SH, Sharma V, Neculai D, Hussein S, Sam M, Trinh Q, Church GM, McPherson JD, Nagy A, Batada NN. Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells. Stem Cells, 30 (3), p. 435-40, 2012, ISSN: 1066-5099.
Bisson N, Ruston J, Jeansson M, Vanderlaan R, Hardy WR, Du J, Hussein SM, Coward RJ, Quaggin SE, Pawson T. The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier. PLoS ONE, 7 (11), p. e50996, 2012.
Hussein SM, Nagy K, Nagy A. Human induced pluripotent stem cells: the past, present, and future. Clin Pharmacol Ther, 89 (5), p. 741-5, 2011, ISSN: 0009-9236.
Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Narva E, Ng S, Sourour M, Hamalainen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brustle O, Bazett-Jones DP, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T. Copy number variation and selection during reprogramming to pluripotency. Nature, 471 (7336), p. 58-62, 2011, ISSN: 0028-0836.
Rajala K, Lindroos B, Hussein SM, Lappalainen RS, Pekkanen-Mattila M, Inzunza J, Rozell B, Miettinen S, Narkilahti S, Kerkela E, Aalto-Setala K, Otonkoski T, Suuronen R, Hovatta O, Skottman H. A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells. PLoS ONE, 5 (4), p. e10246, 2010.
Hussein SM, Duff EK, Sirard C. Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2.J Biol Chem, 278 (49), p. 48805-14, 2003, ISSN: 0021-9258.